CALPHOSTIN C
- Product Name
- CALPHOSTIN C
- CAS No.
- 121263-19-2
- Chemical Name
- CALPHOSTIN C
- Synonyms
- UCN-1028C;2-Diazole;PKF 115-584;CALPHOSTIN C;Cladochrome E;(R)-Calphostin C;Calphostin C,98%;He Ding C Carver;Calphostin CUCN-1028C;UCN 1028 C, PKF 115-384
- CBNumber
- CB7457711
- Molecular Formula
- C44H38O14
- Formula Weight
- 790.76
- MOL File
- 121263-19-2.mol
CALPHOSTIN C Property
- Boiling point:
- 1039.8±65.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 1 mg/mL
- form
- powder
- pka
- 7.30±0.20(Predicted)
- color
- red to brown
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 24/25-36-26
- WGK Germany
- 3
- HS Code
- 29209010
- Hazardous Substances Data
- 121263-19-2(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- C6303
- Product name
- Calphostin C from Cladosporium cladosporioides
- Purity
- ≥90% (HPLC), powder
- Packaging
- 0.1mg
- Price
- $254.4
- Updated
- 2024/03/01
- Product number
- C6303
- Product name
- Calphostin C from Cladosporium cladosporioides
- Purity
- ≥90% (HPLC), powder
- Packaging
- 1mg
- Price
- $812
- Updated
- 2024/03/01
- Product number
- 208725
- Product name
- Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem
- Purity
- Acellpermeable,highlyspecificinhibitorofproteinkinaseC(IC??=50nM)t
- Packaging
- 50μg
- Price
- $154
- Updated
- 2023/01/07
- Product number
- 208725
- Product name
- Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem
- Purity
- Acellpermeable,highlyspecificinhibitorofproteinkinaseC(IC??=50nM)t
- Packaging
- 100μg
- Price
- $264
- Updated
- 2023/01/07
- Product number
- J60647
- Product name
- Calphostin C, 95%
- Packaging
- 100microg
- Price
- $238
- Updated
- 2023/06/20
CALPHOSTIN C Chemical Properties,Usage,Production
Chemical Properties
Dark red solid
Uses
Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.
Uses
Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.
Uses
Potent inhibitor of protein kinase C
Biological Activity
Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM).
Biochem/physiol Actions
Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.
storage
+4°C (desiccate)
CALPHOSTIN C Preparation Products And Raw materials
Raw materials
Preparation Products
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